Browsing by Author "Alpman, Ahmet"

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    Aritmiler
    (2017) Alpman, Ahmet
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    Metabolik sendromun elektif perkütan koroner girişim sonrası kontrast madde nefropatisi gelişimine etkisi
    (Tıp Fakültesi, 2015) Er, Hacer; Alpman, Ahmet; Tıp
    Contrast Induced Nephropathy (CIN) is the third most common cause of acute kidney injury that develops in hospitalized patients. Moreover, it is related to increased morbidity and mortality, long hospital stays and potential risk of dialysis. In order to prevent these complications, patients that are prone to develop CIN need to be identified and prophylactic methods need to be applied. Aim; It is aimed to investigate the effects of metabolic syndrome (MetS) on development of CIN in patients undergoing an elective percutaneous coronary intervention (PCI) who are not diagnosed as having diabetes mellitus (DM). Material and Method; This is a retrospective study. A total of 366 patients who are not diagnosed with DM are divided into two groups. 153 patients are studied in the group of patients with MetS, 213 patients are studied in the group of patients without MetS. MetS is defined with respect to the NCEP-ATP III criteria. CIN is defined as having an increase of ≥25% or ≥0.5 mg/dl in the basal serum creatinine level within 48-72 hours after coronary angiography. Results; The average age of the patients is 61.3. It is found by examining the clinical, biochemical and procedural characteristics of both groups that, female gender, üric acid levels, body mass index and MetS parameters are higher (p<0.05) in MetS group. After the procedure, an increase in creatinine levels is observed in both groups (from 0.97±0.18 to 1.18±0.53, p<0.01 in MetS group and from 0.97±0.17 to 1.03±0.24, p=0.03 in control group). CIN is observed at a rate of 6.5% (10 of 153) in MetS group and at a rate of 2.8% (6 of 213) in control group (p=0.08). Discussion: Even though the observed rate of CIN in patients undergoing elective PCI who are not diagnosed as having DM is higher in patients with MetS compared to those without MetS, this difference was not found to be statistically significant (p=0.08). Larger, multicenter, randomized trials need to be launched addressing this issue.