MAKALELER

Permanent URI for this community

https://dspace.ankara.edu.tr/handle/20.500.12575/4809
Bu koleksiyonda Ankara Üniversitesi bünyesinde yayınlanmış ya da yayınlanmamış, Ulusal ve Uluslararası indekslerde yer alan bilimsel dergilerde yayınlanmış veya yayınlanabilir kararı verilmiş makaleler yer almaktadır.

Browse

Browsing MAKALELER by Subject "1, 3, 4-thiadiazole,"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide
    (2018) Süzen, Sibel; Eczacılık Fakültesi; Sirinzadeh, Hanif; Altanlar, Nurten; Westwell, Andrew D.
    Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy. Materials and Methods: The efficacy of new compounds was evaluated using 2-fold serial dilutions against Staphylococcus aureus, MRSA, Escherichia coli, Bacillus subtilis, Candida albicans, and Candida krusei. Results: The MIC was determined for test compounds and for the reference standards sultamicillin, ampicillin, fluconazole, and ciprofloxacin. Conclusion: The compounds possessed a broad spectrum of activity having MIC values of 3.125-50 µg/mL against the tested microorganisms. This study provides valuable evidence that the indole-triazole derivative compound 3d holds significant promise as a novel antibacterial and antifungal lead compound.