Synthesis and antioxidant activity evaluations of melatonin-based analogue indole-hydrazide/hydrazone derivatives

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherYilmaz, Ayşe Didem
dc.contributor.otherÇoban, Tülay
dc.date.accessioned2020-03-18T08:56:32Z
dc.date.available2020-03-18T08:56:32Z
dc.date.issued2012
dc.description.abstractMelatonin (MLT) is a hormone synthesized from the pineal gland. It is a direct scavenger of free radicals, which is related to its capability to defend cells from oxidative stress. Recently MLT-related compounds are under investigation to establish which exhibit the maximum activity with the lowest side effects. In this study 5-chloroindole hydrazide/hydrazone derivatives were synthesized from 5-chloroindole-3-carboxaldehyde and phenyl hydrazine derivatives. All the compounds characterized and in vitro antioxidant activity was investigated against MLT and BHT. Most of the compounds showed strong inhibitory effect on the superoxide radical scavenging assay at 1mM concentration (79 to 95%). Almost all the tested compounds possessed strong scavenging activity against the DPPH radical scavenging activity with IC 50 values (2 to 60 μM). Lastly, compound 1j revealed stronger inhibitory activity against MLT in the LP inhibitory assay at 0.1mM concentration (51%) while the rest of the compounds showed moderate inhibition. © 2012 Informa UK, Ltd.tr_TR
dc.description.indexwos
dc.description.indexScopus
dc.identifier.endpage436tr_TR
dc.identifier.issue3tr_TR
dc.identifier.startpage428tr_TR
dc.identifier.urihttps://doi.org/10.3109/14756366.2011.594048tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70728
dc.identifier.volume27tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3109/14756366.2011.594048tr_TR
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistrytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAntioxidant activitytr_TR
dc.subjectHydrazonetr_TR
dc.subjectMelatonintr_TR
dc.subjectSynthesistr_TR
dc.subjectIndoletr_TR
dc.titleSynthesis and antioxidant activity evaluations of melatonin-based analogue indole-hydrazide/hydrazone derivativestr_TR
dc.typeArticletr_TR

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