Inflammatory markers C-reactive protein and PLR in relation to HCC characteristics

dc.contributor.authorÖrmeci, Necati
dc.contributor.departmentTıp Fakültesitr_TR
dc.date.accessioned2020-12-30T12:56:06Z
dc.date.available2020-12-30T12:56:06Z
dc.date.issued2019
dc.description.abstractIntroduction: Several markers of systemic inflammation, including blood C-reactive protein, platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) have been identified as independent prognosticators for hepatocellular carcinoma (HCC). Methods: To attempt to understand the significance of these markers, they were examined in relation to 4 tumour parameters, namely maximum tumour diameter (MTD), tumour multifocality, portal vein thrombosis (PVT) and blood alpha-fetoprotein (AFP) levels. Results: Using linear and logistic regression models, we found that C-reactive protein and PLR on single variables, were statistically significantly related to the tumour parameters. In a logistic regression final model, CRP was significantly related to MTD, AFP and PVT, and the Glasgow Index significantly related to MTD and AFP. Results of the area under the receiver operating characteristic curves (ROC), showed that the areas for PLR and CRP were statistically significant for high versus low MTD and for presence versus absence of PVT. CRP alone was significant for high versus low AFP. Conclusions: These analyses suggest that the prognostic usefulness of the inflammatory markers PLR and CRP (but not NLR) may be due to their reflection of parameter values for tumour growth and invasiveness.tr_TR
dc.description.indexPubmed
dc.identifier.endpage14tr_TR
dc.identifier.issue3tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.urihttps://doi.org/10.15761/JTS.1000260tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/72604
dc.identifier.volume5tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.15761/JTS.1000260tr_TR
dc.relation.journalJ Transl Sci .tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectC-reactive proteintr_TR
dc.subjectHCCtr_TR
dc.subjectaggressivenesstr_TR
dc.titleInflammatory markers C-reactive protein and PLR in relation to HCC characteristicstr_TR
dc.typeArticletr_TR

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