Antimicrobial evaluation of indole-containing hydrazone derivatives

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherShirinzadeh, Hanif
dc.contributor.otherAltanlar, Nurten
dc.contributor.otherYücel, Nihal
dc.contributor.otherÖzden, Seçkin
dc.date.accessioned2020-03-18T08:27:05Z
dc.date.available2020-03-18T08:27:05Z
dc.date.issued2011
dc.description.abstractThere has been an increasing importance of drug-resistant pathogens in clinical microbiological and antibacterial research. Indoles and hydrazone-type compounds constitute important classes of compounds in the search for effective agents against multidrug-resistant microbial infections. In this study a series of 1-methylindole-3-carboxaldehyde hydrazone derivatives were evaluated for their in vitro antimicrobial activities using the two-fold serial dilution technique against Staphylococcus aureus, methicillin-resistant S. aureus, methicillin-resistant S. aureus isolate, Escherichia coli, Bacillus subtilis, and Candida albicans. The minimum inhibitory concentration (MIC) of the test compounds and the reference standards sultamicillin, ampicillin, fl uconazole, and ciprofl oxacin was determined. All compounds possessed a broad spectrum of activity having MIC values of 6.25-100 μg/ml against the tested microorganisms. Aromaticity and disubstitution of the phenyl ring with especially fl uorine and chlorine atoms were found to be signifi cant for the antimicrobial activity. © Verlag der Zeitschrift für Naturforschung, Tübingen.tr_TR
dc.description.indexwos
dc.description.indexScopus
dc.identifier.endpage344tr_TR
dc.identifier.issue7-8tr_TR
dc.identifier.startpage340tr_TR
dc.identifier.urihttps://doi.org/10.1515/znc-2011-7-804tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70727
dc.identifier.volume66 Ctr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1515/znc-2011-7-804tr_TR
dc.relation.journalZeitschrift fur Naturforschung - Section C Journal of Biosciencestr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAntimicrobialtr_TR
dc.subjectHydrazonetr_TR
dc.subjectIndoletr_TR
dc.titleAntimicrobial evaluation of indole-containing hydrazone derivativestr_TR
dc.typeArticletr_TR

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