Comparative effect of N-substituted dehydroamino acids and α-tocopherol on rat liver lipid peroxidation activitie

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherFerreira, Paula M.
dc.contributor.otherMonteiro, Luís S.
dc.contributor.otherÇoban, Tülay
dc.date.accessioned2020-03-18T07:32:19Z
dc.date.available2020-03-18T07:32:19Z
dc.date.issued2009
dc.description.abstractFree radical damage has been associated with a growing number of diseases and conditions, such as autoimmune diseases, neurodegenerative disorders and multiple types of cancer. Some dehydroamino acids and corresponding peptides can function as radical scavengers. In this study the in vitro effects on rat liver lipid peroxidation levels of fourteen N-substituted dehydroamino acid derivatives and alpha-tocopherol were investigated. alpha-Tocopherol is a powerful antioxidant that is beneficial in the treatment of many free radical related diseases. The results indicated that all the compounds showed very good inhibitory effect on the lipid peroxidation compound with alpha-tocopherol at 1 mM concentrations and the inhibition rate was in the range of 70-79 % with the exception of compound 5. At 0.1 mM concentrations compounds 1, 2 and 9 were found more active than alpha-tocopherol. The results confirmed that molecules such as dehydroamino acids which have reactive double bonds can act as a guard in vitro against oxidants.tr_TR
dc.description.indexWos
dc.description.indexScopus
dc.identifier.endpage971tr_TR
dc.identifier.issn/e-issn1475-6366
dc.identifier.issn/e-issn1475-6374
dc.identifier.issue4tr_TR
dc.identifier.startpage967tr_TR
dc.identifier.urihttps://doi.org/10.1080/14756360802561162tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70720
dc.identifier.volume24tr_TR
dc.language.isoentr_TR
dc.publisherJournal of Enzyme Inhibition and Medicinal Chemistrytr_TR
dc.relation.isversionof10.1080/14756360802561162tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectDehydroamino acidtr_TR
dc.subjectA-tocopheroltr_TR
dc.subjectLipid peroxidationtr_TR
dc.subjectRadical scavengingtr_TR
dc.subjectAntioxidantr_TR
dc.titleComparative effect of N-substituted dehydroamino acids and α-tocopherol on rat liver lipid peroxidation activitietr_TR
dc.typeArticletr_TR

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