Genome projects 5W1H: What, where, when, why, how and in which population?

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dc.contributor.authorÖzdag, Hilal
dc.contributor.authorIDhttp://orcid.org/0000-0001-7940-2499tr_TR
dc.contributor.departmentBiyoteknoloji Enstitüsütr_TR
dc.contributor.otherFidanoğlu, Pelin
dc.contributor.otherBelder, Nevin
dc.contributor.otherErdoğan, Beyza Doğanay
dc.date.accessioned2020-04-29T07:15:27Z
dc.date.available2020-04-29T07:15:27Z
dc.date.issued2014
dc.description.abstractGenome projects aim to decode an organism's complete set of deoxyribonucleic acid (DNA), which can be described as the living code of organism. The idea of the Human Genome Project (HGP) was conceived in the early 1980s. The project was started at 1990 and finished at 2003. The sequencing of the whole human genome derived from the DNA of several anonymous volunteers, costed 3.8 billion dollars. In order to annotate the genome data, the "topography of the genome" and the anatomy of the genes should have been revealed. For this purpose, genome projects of several model organisms was carried out in parallel with HGP with the aim to identify basic structural components, organizational structure and evolutionarily development of the genome. With the advent of microarray technology in the early 2000s, high-throughput screening of Single Nucleotide Polymorphisms (SNPs) and Copy Number Variations (CNVs) became feasible. After the completion of HGP in 13 years, James D. Watson's genome was sequenced with 1 million dollar budget in just 2 months using next generation sequencing technology. Today a human genome can be sequenced in just one day with the cost of 6.600 USD. In this reviev the HGP which created big expectations especially in medicine will be explained from its start to the present. Then we will summarize the studies paving the road to personalized medicine emphasizing the fact that to reveal the meaning of genomic information, it should become computable.tr_TR
dc.description.indexScopus
dc.identifier.endpage60tr_TR
dc.identifier.issue1tr_TR
dc.identifier.startpage45tr_TR
dc.identifier.urihttps://doi.org/10.5505/TurkHijyen.2014.14890tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71198
dc.identifier.volume71tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.5505/TurkHijyen.2014.14890tr_TR
dc.relation.journalTurk Hijyen ve Deneysel Biyoloji Dergisitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectHaplotypetr_TR
dc.subjectHGPtr_TR
dc.subjectSNPtr_TR
dc.subjectVariationtr_TR
dc.titleGenome projects 5W1H: What, where, when, why, how and in which population?tr_TR
dc.title.alternativeGenom projeleri 5N1H: Ne, nerede, ne zaman, nasil, neden ve hangi popülasyonda?tr_TR
dc.typeArticletr_TR

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