Mesalamine Intolerance in Three Children with Crohn's Disease

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dc.contributor.authorKirsaclioglu, Ceyda Tuna
dc.contributor.authorKuloglu, Zarife
dc.contributor.authorUstundag, Gonca
dc.contributor.authorKansu, Aydan
dc.contributor.authorInce, Erdal
dc.contributor.authorEnsari, Arzu
dc.contributor.authorGirgin, Nurten
dc.contributor.departmentTIP FAKÜLTESİtr_TR
dc.date.accessioned2019-07-01T12:04:01Z
dc.date.available2019-07-01T12:04:01Z
dc.date.issued2016
dc.description.abstractObjective: To present the mesalamine-induced acute exacerbation of symptoms and inflammatory markers in children with Crohn's disease (CD). Clinical Presentation and Intervention: Three children who presented with CD had acute exacerbation of colitis symptoms or elevated inflammatory markers when mesalamine was added to treatment while tapering/ceasing steroid treatment. While on steroid treatment, the patients maintained clinical and laboratory remission, but with the initiation of mesalamine treatment, they had abdominal pain and bloody mucoid diarrhoea and/or elevation of white blood cell count, C-reactive protein level and erythrocyte sedimentation rate. Bacterial pathogens were excluded from the urine, throat and blood cultures, parasites with stool examination, viral pathogens with serology. Within 3-7 days after the mesalamine treatment had been stopped, the patients showed improvement of colitis symptoms and normalisation of white blood cell count, C-reactive protein level and erythrocyte sedimentation rate. Conclusion: In this study mesalamine mimicked CD relapse in children with CD while tapering or after stopping steroid treatment. Awareness of this side effect of mesalamine could prevent a misdiagnosis of steroid dependency. (C) 2015 S. Karger AG, Baseltr_TR
dc.description.indexWos
dc.description.indexwos
dc.identifier.endpage03tr_TR
dc.identifier.other10.1159/000442946
dc.identifier.startpage01tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/67043
dc.language.isoentr_TR
dc.relation.indexWOStr_TR
dc.relation.journalMEDICAL PRINCIPLES AND PRACTICEtr_TR
dc.subjectChildrentr_TR
dc.subjectCrohn's diseasetr_TR
dc.subjectMesalaminetr_TR
dc.titleMesalamine Intolerance in Three Children with Crohn's Diseasetr_TR
dc.typeArticletr_TR

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