WOUND HEALING EFFECT OF NARINGIN GEL IN ALLOXAN INDUCED DIABETIC MICE

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dc.contributor.authorOkur, Mehmet Evren
dc.contributor.departmentOthertr_TR
dc.contributor.facultyOthertr_TR
dc.date.accessioned2022-10-25T11:40:37Z
dc.date.available2022-10-25T11:40:37Z
dc.date.issued2020
dc.description.abstractObjective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound. Material and Method: In vitro direct contact assay and hen’s egg chorio-allantoin membrane tests were used to evaluate irritation, and cytotoxicity potential of Naringin. In vitro antimicrobial activity was also tested. Topical treatments were administered once a day on the wound. Wound lesions were photographed and statistically analyzed. After the 10th day, histopathological parameters of tissues were assessed. Result and Discussion: The results showed that naringin gel has no cytotoxicity and irritation potential. Also, it displayed a weak antimicrobial effect. Aside from these, in vivo studies revealed that naringin gel showed statistically higher wound contraction and re-epithelialization, the thickness of granulation tissue, angiogenesis scores. The results indicated that naringin gel effectively enhanced diabetic wound healing, and so this formulation could be considered a promising therapeutic alternative for treating diabetic wounds.tr_TR
dc.description.indexScopustr_TR
dc.description.indexTrdizintr_TR
dc.identifier.endpage414tr_TR
dc.identifier.issn/e-issn1015-3918
dc.identifier.issue3tr_TR
dc.identifier.startpage397tr_TR
dc.identifier.urihttps://doi.org/10.33483/jfpau.742224tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/84866
dc.identifier.volume44tr_TR
dc.language.isoentr_TR
dc.publisherAnkara Üniversitesitr_TR
dc.relation.isversionof10.33483/jfpau.742224tr_TR
dc.relation.journalAnkara Üniversitesi Eczacılık Fakültesi Dergisitr_TR
dc.relation.publicationcategoryGazete Makalesi - Ulusaltr_TR
dc.subjectCell culturetr_TR
dc.subjectDiabetes mellitustr_TR
dc.subjectHET-CAMtr_TR
dc.titleWOUND HEALING EFFECT OF NARINGIN GEL IN ALLOXAN INDUCED DIABETIC MICEtr_TR
dc.typeArticletr_TR

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Cilt:44 Sayı:03(2020)