Keten tohumu ve diyabetik kardiyovasküler komplikasyonlar
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Date
2012
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Sağlık Bilimleri Enstitüsü
Abstract
Cardiovascular diseases have an increasing rate of incidence and causes morbiditiy and mortality. Cardiovascular diseases are observed more in diabetic patients. Flaxseed is cardioprotective because of its positive effects on lipid levels and endothelial functions and its antioxidant impact. To search the effect of flaxseed in diabetes female streptozotocin (STZ)-diabetic rats were treated with flaxseed (0,714 g/kg/day; orally) during 12 weeks. The rats were divided into four groups: control (C), control treated (CT), diabetic (D) and diabetic treated (DT). At the end of the study, body weight, blood pressure, blood glucose, serum HDL cholesterol (HDL-C), insülin, GOT, GPT levels were measured and cumulative contraction (10-9-10-4M) responses curves were obtained with phenylephrine (Phe) on isolated thorasic aortic rings. Aortas incubated 20 minutes with indomethacin (10-5M; nonspecific inhibitor) to research the cyclooxygenase (COX) pathway, L-nitro arginin methyl ester (L-NAME; 10-5M) (endothelial nitric oxide synthase inhibitor) to research the effect of NO and superoxide dismutase (SOD; 1500 U) to determine the role of superoxide radicals and cumulative response curves were obtained with Phe. Flaxseed treatment significantly decreased the blood pressure levels in control groups. In spite of an increase in serum HDL-C level in diabetic treated group, a decrease in control treated group occured. Although the glucose level of diabetic treated groups were decreased significantly, there was no change in the control treated group. The treatment decreased the level of serum insülin in both groups. At the same time, it decreased the rise of GPT level in D groups. The maximum level of contraction with Phe was seen in D group, while a similiar level was observed in KT group. On the other hand, the responses were similiar in K and DT groups. Following the indomethacin incubation, there was a significant decrease in contraction levels of all groups particularly the D group. After L-NAME incubation, there were increases in contraction levels in all groups except in D group. The contraction levels of DT and K groups were close. SOD incubation decreased the contraction levels mostly in diabetic group. Despite the decrease in contraction levels of DT group, that was much lower compared to D, opposite effects were observed in KT group. As a result, it is seen that flaxseed treatment had a positive effect on hyperglycemia and on vascular contractile responses in D group, but the similar positive effects did not occur in control groups. Therefore, flaxseed must be used in necceasary conditions.
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Keten tohumu, diyabetik kardiyovasküler komplikasyon