Partisyon katsayısı (log p) tahmininde kullanılan yazılımların karşılaştırılması
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Date
2019
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Publisher
Ankara : Ankara Üniversitesi
Abstract
Objective: Drug candidate compounds that are going to be synthesized have to reach body tissues and
show minimum toxic effects within the body. Partition coefficient (log P), which is a physicochemical parameter
of Quantitative Structure- Activity Relationship subject, effects the pharmacokinetical characteristic of the
compound. In this context, researchers tend to use log P prediction softwares to save both time and resources
in their drug development studies. Although, these softwares do not give a true value. In this study, softwares
that have being used were tested. The one that gets approved for its accuracy can give some clues on the value
of partition coefficient, before determining it experimentally.
Description
Keywords
İlaç Geliştirme, Lipofiliklik