Türkiye'de yetişen Heptaptera cinsi türleri (Umbelliferae) üzerinde farmasötik botanik yönünden araştirmalar
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Date
2010
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Sağlık Bilimleri Enstitüsü
Abstract
This study has been performed on four Heptaptera species (H. cilicica, H. anisoptera, H. anatolica, H. triquetra) growing naturally in Turkey. In the study, morphological and anatomical features, chemical components and biological activities were investigated.The morphological and anatomical features of the species were examined; similarities and differences were revealed with photographs and drawings. In addition, surfaces of all fruits, pollen and seed morphologies were examined and their photographs were taken with light and scanning electron microscopes.In the chemical study, main active substance groups of the roots, herba and fruits of the species were tried to be determined. Coumarin type compounds, found in the roots, herba and fruits of each species were determined with TLC analysis. In addition, flavonoids, present in the roots, herba and fruits of each species were qualitatively examined.Essential oils, obtained from the fruits of four Heptaptera species growing in Turkey were analyzed with GC and GMS methods and the major components of each essential oil were determined.In biological activity studies, antimicrobial, antioxidant activities and acetylcholinesterase enzyme inhibition activities were determined.Antioxidant activity studies were performed by using DPPH free radical scavenging activity, iron ion chelating activity and total phenol determination methods. The highest PPH activity was observed at a concentration of 2000 µg ml-1 as 86.19% and 80.48% in the fruit and herba extracts of H. triquetra, respectively.In the methanolic extract of fruits (190.68 mg-1) and herba (112.3 mg-1) of H. triquetra, the highest total phenol activities were observed. At a concentration of 2000 µg ml-1, the highest iron chelating activity was observed in the ethyl acetate extract of the fruits and herba of H. triquetra as 96.28% and 94.94%, respectively.Methanolic and ethyl acetate extract of four species belonging to the genus Heptaptera are examined in respect to Acetylcholinesterase enzyme inhibition. At a concentration of 2000 µg ml-1, moderate activity as 49.80% and 61.97% was seen in the fruit and herba extract of H. anatolica, respectively.Keywords: Anatomy, Biological activity (antioxidant, acetlycholinesterase)Coumarin, Essential oil, Heptaptera, Morphology,
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Anatomi, Heptaptera